For active, sodium chromate: chromic acid, disodium chromate salt, tetrahydrate (crystalline form).

For active, sodium chromate: chromic acid, disodium chromate salt, tetrahydrate (crystalline form).
Bracco Diagnostics, Inc.

Sodium Chromate Cr51 Injection

MSDS Name: Sodium Chromate Cr51 Injection
Manufacturer Name: Bracco Diagnostics, Inc.
Address:
P.O. Box 5225
Princeton, NJ 08543

EMERGENCY CONTACTS:
(U.S. Transportation) Chemtrec: 1-800-424-9300.
(International Transportation) Chemtrec: 1-703-527-3887.
Health Phone: 1-800-257-5181
Regulatory Information Phone: Nuclear Regulatory Commission: 1-800-368-5642.
Manufacturer MSDS Revision Date: May, 18 2001
Supersedes: March 20, 2001
Supersedes: March 6, 1992
Synonyms:
For active, sodium chromate: chromic acid, disodium chromate salt, tetrahydrate (crystalline form).
CAS Number: 7775-11-3 (pertains to sodium chromate).
Chemical Family: Radioisotope of chromium (VI) (hexavalent oxidation state)
Physical Form:
Clear, aqueous solution.
Color: Light yellow
General Use:
Determination of red blood cell volume or mass, study of red blood cell survival time.
Chemical Name: For active, Cr51: sodium chromate 51.

How Supplied: Multidose reaction vials of 1.25 mL or 5 mL.

Molecular Formula: 51CrO4.2Na (radioisotope)

The author of this Material Safety Data Sheet (MSDS) is Bracco Diagnostics Inc. This MSDS is generated and/or distributed by the Bristol-Myers Squibb Company on behalf of Bracco Diagnostics Inc. Please carefully review all of the information disclosed in this MSDS prior to handling or using the product referenced above.

EMERGENCY OVERVIEW:
Formulation contains RADIOACTIVE CHROMIUM 51. As in the use of any radioactive material, care should be taken to insure minimum radiation exposure. Personnel who handle radioactive materials should be trained in their use and should follow appropriate precautions for work with these materials. See Health Effects and Toxicology sections for additional information.
SECTION 2 : COMPOSITION, INFORMATION ON INGREDIENTS
Chemical Name
Sodium Chromate Cr-51
CAS#
7775-11-3**
% Weight
CONCENTRATION: Not applicable*
ACGIH TLV TWA: 50 Sv/year, 0.05 mg/m3 as Cr
Hazardous: Yes
Comments:
*See specifications for radioactivity on package.
**CAS number pertains to sodium chromate.
Composition/Information:
COMPONENTS (> 1%)

Components present at < 1% or used for pH adjustment: sodium chromate, benzyl alcohol (preservative), sodium chloride, hydrochloric acid, sodium bicarbonate.
SECTION 3 : HAZARDS IDENTIFICATION
Emergency Overview:
Formulation contains RADIOACTIVE CHROMIUM 51. As in the use of any radioactive material, care should be taken to insure minimum radiation exposure. Personnel who handle radioactive materials should be trained in their use and should follow appropriate precautions for work with these materials. See Health Effects and Toxicology sections for additional information.
Physical State:
Clear, aqueous solution
Color: Light yellow
Applies to all ingredients:
Route of Exposure:
Inhalation, Skin Contact, Ingestion
Potential Health Effects:
Eye Contact:
Acute: May cause irritation. Goggles should be worn when handling large amounts of this material.
Skin Contact:
Exposure may occur via skin contact if gloves and protective clothing are not worn.
Inhalation:
Under normal conditions, this liquid material is handled in closed vials and exposure by inhalation is not expected to occur.

Acute: Formulation contains some materials that are irritants. Inhaling small amounts of liquid aerosol may result in nasal and other respiratory tract irritation. In general, depending on both the dose and duration, exposure to radioactive materials may produce adverse effects. Toxic effects of radiation may include development of cancer, adverse reproductive effects, including adverse effects on the fetus.
Ingestion:
Ingestion of large quantities of this material in an occupational setting would not be expected to occur. Ingestion of trace amounts of the material might occur if the material contacts hands and hands are not washed prior to eating, drinking or smoking.

Acute: Inadvertent ingestion of trace amounts of this material would not be expected to result in symptoms. However, ingestion of substantial amounts may cause kidney damage (acute tubular necrosis). In general, depending on both the dose and duration, exposure to radioactive materials may produce adverse effects. Toxic effects of radiation may include development of cancer, adverse reproductive effects, including adverse effects on the fetus.
Chronic Health Effects:
Repeated and prolonged exposure to skin may cause skin ulcers.
Sodium Chromate Cr-51:
Potential Health Effects:
Skin Contact:
Hexavalent chromium compounds are readily absorbed through damaged skin.

Acute:
a. Toxic: Contact with small quantities of material for short periods is not expected to result in pharmacologic or toxic effects. Substantive occupational exposure to hexavalent chromium through damaged skin may produce kidney damage.

b. Irritation: This material contains Hexavalent chromium which is an irritant. Sufficient exposure may cause skin ulcers.

c. Sensitization: Hexavalent chromium compounds may cause allergic contact dermatitis.
Ingestion:
Hexavalent chromium is readily absorbed after ingestion.
Carcinogenicity:
Carcinogen Lists for hexavalent chromium:
OSHA Designation: YES
NTP Designation: YES
IARC Designation: YES
Target Organs:
Target organs for hexavalent chromium: Blood, respiratory system, kidneys, liver, eyes and skin.
Aggravation of Pre-Existing Conditions:
Renal disease. Skin disorders may be aggravated by exposure to hexavalent chromium compounds.

Exposure Guideline Summary:
An exposure guideline of 0.05 mg/cubic meter has been established for water soluble hexavalent chromium by the American Conference of Governmental Industrial Hygienists (ACGIH). OSHA has a ceiling value of 0.1 mg/cubic meter for hexavalent chromium compounds. The occupational guideline for exposure to radioactive materials is an effective dose equivalent to 50 mSv per year.
SECTION 4 : FIRST AID MEASURES
Eye Contact:
Hold eyelids apart and flush with plenty of water for 5 minutes. Get medical attention if signs of irritation develop.
Skin Contact:
Remove contaminated clothing. Wash skin with plenty of water for 5 minutes. Seek medical attention if irritation (redness, itching or swelling) develops or persists.
Inhalation:
Remove exposed person to fresh air. If person is not breathing, give artificial respiration. If breathing is difficult administer oxygen. Get medical attention immediately.
Ingestion:
Get medical attention immediately. Vomiting may be induced if a person is conscious and if ingestion has occurred within the past three hours. Never induce vomiting in a person who is unconscious or experiencing convulsions.
Other First Aid:
Note: When transporting an employee for medical assistance, after the employee has had direct contact with a radioactive material, care should be taken to avoid contamination of transport vehicle and medical facility. Skin decontamination and monitoring should be conducted as appropriate.
SECTION 5 : FIRE FIGHTING MEASURES
Flash Point:
Not available.
Upper Flammable or Explosive Limit:
Not applicable.
Lower Flammable or Explosive Limit:
Not applicable.
Auto Ignition Temperature:
Not available.
Extinguishing Media:
In case of fire, flood with water.
Hazardous Combustion Byproducts:
Carbon monoxide, carbon dioxide, radioactive chromate.

Combustibility of Dusts:
Not applicable, product exists as a liquid.
Fire Fighting Instructions:
Firefighters should wear self-contained breathing apparatus, flame and chemical resistant clothing, boots and gloves. Evacuate personnel to an upwind direction, remove unneeded material and cool container(s) with water from a maximum distance.
Sensitivity to Impact:
Explosion data relative to mechanical impact: No information.
Static Discharge Effects:
Explosion data relative to static discharge: No information.
Unusual Fire Hazards:
Material is radioactive.
SECTION 6 : ACCIDENTAL RELEASE MEASURES
Spill Cleanup Measures:
Radioactive shielding if appropriate to minimize exposure, lab coat, impermeable gloves (latex, latex/nitrile or nitrile) and chemical safety goggles. Absorb liquid onto appropriate absorbent material and place into an appropriate container for disposal. The spill area should be ventilated and decontaminated after material has been picked up. Dispose of radioactive material in accordance with all local, state, federal and NRC regulations or with the regulations of the country in which the material is used.
SECTION 7 : HANDLING and STORAGE
Handling:
Avoid skin and eye contact.
Storage:
Store at 20-25 deg C.
Hygiene Practices:
Wash hands after handling product and before eating, smoking, using lavatory and at the end of the day.

Container Requirements:
Lead vial shield and lead cover must remain in place on the reaction vial. Chromitope Sodium is available in multiple dose 1.25 mL vials containing 9.25 megabecquerels (250 microcuries) and multiple dose 5.0 mL vials containing 37 megabecquerels (1.0 millicurie).
SECTION 8 : EXPOSURE CONTROLS, PERSONAL PROTECTION
Ventilation System:
None beyond good room ventilation.
Hand Protection Description:
Protective Gloves: Wear impervious gloves (latex, latex/nitrile, or nitrile) if the potential exists for dermal contact.
Eye/Face Protection:
Wear safety glasses (ANSI Z87.1). In the event of a spill wear chemical safety goggles.
Protective Clothing/Body Protection:
Special: None.
Respiratory Protection:
Not anticipated for normal clinical environment. Non-routine exposure conditions may require NIOSH approved respiratory protection appropriate for potential exposure to radionuclides. Self-contained breathing apparatus should be available for emergency use.
Exposure Limits:
Exposure Guideline Summary:
An exposure guideline of 0.05 mg/cubic meter has been established for water soluble hexavalent chromium by the American Conference of Governmental Industrial Hygienists (ACGIH). OSHA has a ceiling value of 0.1 mg/cubic meter for hexavalent chromium compounds. The occupational guideline for exposure to radioactive materials is an effective dose equivalent to 50 mSv per year.

Hygiene:
Wash hands after handling product and before eating, smoking, using lavatory and at the end of the day.
SECTION 9 : PHYSICAL AND CHEMICAL PROPERTIES
Physical State/Appearance:
Clear, aqueous solution
Color:
Light yellow
Physical State:
Aqueous solution.
pH:
7.5 to 8.5.
Vapor Pressure:
Not available.
Vapor Density:
Not available.
Boiling Point:
Not available.
Freezing Point:
Not available.
Melting Point:
Not available.
Solubility:
In Water: Soluble.
Specific Gravity:
Not available.
Evaporation Point:
Not available.
Viscosity:
(cP): Similar to water (98% water).
Odor Threshold:
Not available.
Coefficient of Water/Oil Distribution:
Water soluble.
Flashpoint:
Not available.
Auto Ignition Temp:
Not available.
Upper Flammable Explosive Limit:
Not applicable.
Lower Flammable Explosive Limit:
Not applicable.
SECTION 10 : STABILITY AND REACTIVITY
Chemical Stability:
This formulation contains sodium chromate (Cr51). The Cr51 radioactively decays with a half-life of 27.7 days.
Incompatibilities with Other Materials:
None known.
Reactivity:
Conditions of Reactivity: None known.
Hazardous Polymerization:
None.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, radioactive chromium 51 compounds.

Explosion data relative to mechanical impact: No information.
Explosion data relative to static discharge: No information.
SECTION 11 : TOXICOLOGICAL INFORMATION
Sodium Chromate Cr-51:
Acute Health Effects:
For active ingredient, sodium chromate, unless indicated differently.

Acute ip LD50(mouse)= 32 mg/kg;
Acute ip LD50(rat)= 57 mg/kg.
Acute iv LD50 (cat)= 164 mg/kg.
Skin Effects:
Contact with small quantities of material for short periods is not expected to result in pharmacologic or toxic effects. Substantive occupational exposure to hexavalent chromium through damaged skin may produce kidney damage.
Chronic Effects:
Biological effects from exposure to radioactive materials are based on exposures higher than those permitted in an occupational setting. No harmful effects are expected from Chromitope Sodium under normal use conditions.
Carcinogenicity:
Hexavalent chromium is a known human carcinogen.
Mutagenicity:
DNA damage occurred in chicken embryos when exposed to sodium chromate at a concentration of 2500 nmol/l.
Teratogenicity:
No information.
Sensitization:
Hexavalent chromium compounds may cause allergic contact dermatitis.
Reproductive Toxicity:
No information.
Irritation:
This material contains Hexavalent chromium which is an irritant. Sufficient exposure may cause skin ulcers.
Other Toxicological Information:
RTECS # (U.S.): GB2955000

Toxicological Synergistic Products: No information.
SECTION 12 : ECOLOGICAL INFORMATION
Ecotoxicity:
For sodium chromate:
LC50 (rotifers)= 3.1 ppm/96 hours;
LC50 (fathead minnow)= 3 ppm/96 hours.

Chemical Fate Information:
Not available.
SECTION 13 : DISPOSAL CONSIDERATIONS
Waste Disposal:
Dispose of radioactive material in accordance with all local, state, federal and NRC regulations or with the regulations of the country in which the material is used.
SECTION 14 : TRANSPORT INFORMATION
DOT Shipping Information:
Domestic:
DOT shipping classification: Radioactive material-see US regulations regarding shipment of radioactive materials.

International:
DOT shipping classification: Radioactive material-see US and other nations’ regulations on shipment of radioactive materials.
SECTION 15 : REGULATORY INFORMATION
Applies to all ingredients:
US Federal:
Radioactive material.
Regulatory Paragraph:
STATUTORY INFORMATION (limited to health, safety, environmental)
European International Regulations:
EC Labeling: Radioactive material.
International Chemical Inventory Lists:
Radioactive material.

NOTE: Not meant to be all-inclusive.
SECTION 16 : ADDITIONAL INFORMATION
Label Text:
CHROMITOPE Sodium vial is a sterile, pyrogen-free liquid containing radioactive Chromium 51.

When transporting an employee for medical assistance, after the employee has had direct contact with a radioactive material, care should be taken to avoid contamination of transport vehicle and medical facility. Skin decontamination and monitoring should be conducted as appropriate.

If ingestion of Chromitope Sodium (containing radioactive chromium 51) inadvertently occurs, the individual may be treated by water hydration or diuresis to facilitate elimination of the radioactive material.

Radioactive materials may pose significant health risks if not properly handled. Personnel who handle radioactive materials should be trained in their use and should follow appropriate precautions for work with these materials.

Chromium 51 decays by electron capture and gamma emission with a physical half-life of 27.7 days. The specific gamma ray constant for Chromium 51 is 0.19 R/hour-millicurie at 1 cm. The first half value layer is 0.2 mm of lead (Pb).

Radiopharmaceuticals should be used only by physicians who are qualified by training and experience in the safe use and handling of radionuclides) and whose experience and training have been approved by the appropriate government agency authorized to license the use of radionuclides.

Dispose of radioactive material in accordance with all local, state, federal and NRC regulations or with the regulations of the country in which the material is used.

Diagnostic agents are intended for use under direction of a physician and under the conditions of use described on the label and in the product’s package insert. As a general precaution, personnel who handle these products should avoid contact (ingestion, inhalation, skin and eye contact) with them.

This material safety data sheet is intended for use by personnel who handle this material as part of their job responsibilities and it does not address the diagnostic use of this material. Information concerning the use of this diagnostic agent should be obtained from the product package insert and other appropriate references.
MSDS Revision Date:
May, 18 2001
Supersedes: March 20, 2001
Supersedes: March 6, 1992

March 20, 2001: New MSDS for CHROMITOPE Sodium was developed by Bracco Diagnostics, Inc.

March 6, 1992: Bristol-Myers Squibb MSDS for CHROMITOPE Sodium.
MSDS Author:
The author of this Material Safety Data Sheet (MSDS) is Bracco Diagnostics Inc.
Disclaimer:
The information contained in this MSDS was obtained by Bracco Diagnostics from sources believed to be accurate and reliable and represents information currently on file and known by Bracco. However, Bracco makes no representation, guaranty or warranty, express or implied, with respect to any such information, and specifically disclaims and assumes no liability resulting from the use, misuse or mishandling of either the product or this MSDS.

This MSDS is generated and/or distributed by the Bristol-Myers Squibb Company on behalf of Bracco Diagnostics Inc. Please carefully review all of the information disclosed in this MSDS prior to handling or using the product referenced above.

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